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Dosimetry and radiobiology research activities in DRD NPI involving ion beams

Marie Davídková (Department of Radiation Dosimetry, Nuclear Physics Institute CAS, Czech Republic)

11h00 GANIL seminar room (105)

a coffee will be served 15mn before

The main research activities of the team concentrate to three overlapping and complementary areas: dosimetry of complex radiation fields, radiation biophysics and biology and environmental dosimetry.

In the domain of dosimetry of complex radiation fields, our research is related to studies of cosmic radiation, related radiation protection issues on board aircrafts and spacecrafts, dosimetric and microdosimetric description of therapeutic charge particle beams, and methodology of passive dosimetry using track-etched detectors.

Biological effects of ionizing radiation depend crucially on microscopic radiation quality, namely the spatial structure of energy depositions along the particle track. As a part of our basic research, we seek to define links between radiation track structure and biological consequences of irradiation. Our long-term interest are the biological consequences of radiation action on subcellular level. The studies of direct and indirect effects of proton and heavy ion induced damage of DNA plasmids are performed at the cyclotron of the Nuclear Physics Institute of the CAS and at HIMAC in Japan. Recently, we have successfully started also experimental studies on cellular level. We work with normal neonatal and adult human skin fibroblasts, which represent normal cell lines, and DAOY medulloblastoma cells. Except cell survival, we follow level of apoptosis, senescence, DNA damage expressed as micronuclei formation in dividing cells and gene expression in irradiated cells. In the frame of collaboration with the Proton Therapy Center in Prague, we perform studies on biological efficiency of spread out Bragg peak of actively scanning proton beam.           

The last, not least, research direction of the team is environmental dosimetry dedicated to the occurrence of radionuclides in the environment, studies of anthropogenic influences on the environment, development of new methods of radionuclides determination, radiocarbon dating, and applications of developed analytical methods in research and industry. In general, developed analytical methods are aimed on chemical forms of uneasily determinable radionuclides (almost clear beta emitters), especially: 14C, 3H, 129I, 90Sr together with 89Sr.

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